Modeling of a folded spring supporting MEMS gyroscope

Microelectromechanical systems (MEMS) are integrated mechanical and electrical devices that are fabricated with features micrometers in size. MEMS are used as chemical laboratories on a chip, actuators, sensors, etc. To increase their operational capability, various MEMS sensors are being integrated into sensor systems, whose functionality may not decrease when their size decreases. However, before more advancement can be made in the sensor systems, behavior of individual sensors must be better understood. Without the basic knowledge of how and why MEMS sensors react the way they do, it is impossible to determine how MEMS sensor systems will behave. Out of the many sensors that can be included in the system, a MEMS gyroscope was selected for consideration in this paper. More specifically, the effects that suspension has on the topography of the microgyroscopes were studied. In this thesis, the folded springs that support the MEMS gyroscopes were modeled using analytical and computational methods, whose results were verified using experimentation. The analytical results correlated well with the computational and experimental results. The analytical and computational results for the deformations of the cantilever compared within 0.1%. The differences between the analytical and experimental results were on the order of 10%. Knowledge gained from these studies will help in the development of a through methodology for modeling the microgyroscope. This methodology will facilitate insertion of the microgyroscopes into the sensor systems

Let’s Go! 2022-2023 Educational Programs: A Realist Evaluation

Introduction: Let’s Go! is a community engagement initiative working to improve health behaviors that impact obesity. Let’s Go! provides educational programming for all medical learners and attending staff throughout Maine. A realist evaluation is a theory-led approach to evaluation that seeks to understand what works for whom, in what circumstances, and in what respects an intervention is more likely to succeed. This project used the realist evaluation framework to evaluate Let’s Go! educational programming in 2022-2023.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1030/thumbnail.jp

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia. GATA2 is a transcription factor that plays an essential role in gene regulation during vascular development and hematopoietic differentiation. Our findings indicate that haploinsufficiency of GATA2 underlies primary lymphedema and predisposes to acute myeloid leukemia in this syndrome

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Functional flow and event-driven methods for predicting system performance

As technology continues to advance at an increasingly rapid pace and systems become more complex, evolving into systems of systems, the discipline of systems engineering will become a more important part of the entire system lifecycle. The scope of this thesis is to apply model-based system engineering principles to the system architecture of a system of systems, and to utilize behavior modeling capabilities to conduct an analysis of alternatives for a realistic design reference mission; the work in this thesis is based around a search and rescue mission. Two models of the search and rescue system of systems were prepared utilizing two model-based system engineering approaches and tools. For functional flow the Innoslate tool (from Spec Innovations) was used, and for event-driven the Monterey Phoenix Analyzer tool (from Naval Postgraduate School) was utilized. The application of both approaches illustrated how difficult it is to model a system of systems, and this examination uncovered opportunities to improve both approaches. The ability to allow an asset to asynchronously proceed through a scenario would improve the flexibility of Innoslate. To improve the utility of Monterey Phoenix Analyzer for analyses of alternatives, the capability to automatically input the characteristics for assets should be incorporated.http://archive.org/details/functionalflownd1094547334Outstanding ThesisCivilian, Naval Undersea Warfare CenterApproved for public release; distribution is unlimited

La legalización de la muerte médicamente asistida para personas con depresión mayor intratable : un paso hacia la desestigmatización de los trastornos mentales

Fil: Steward, Victoria May. Universidad de San Andrés. Departamento de Derecho; Argentina

Study of the dynamics of a MEMS accelerometer.

Microelectromechanical systems (MEMS) are integrated mechanical and electrical devices, which can be sensors, valves, gears, mirrors, actuators, and processors that are deposited on semiconductor chips and fabricated with features micrometers in size. In order for these microscopic devices to be utilized, they must be packaged in such a way that their operating specifications are not compromised. The purpose of this MQP was to investigate the dynamics of MEMS accelerometers and evaluate if the packages have an affect on their functionality under a variety operating conditions. To determine this, the accelerometers were examined analytically and computationally, specifically with FEM analysis, to establish how they function. Then, the MEMS accelerometers were operated under conditions of varying temperature and humidity both with and without their packages. The experimental results proved that the packages cannot protect the MEMS components from all environmental conditions, and that research must be done to improve the packages currently available and to determine how changing temperature and humidity affect MEMS sensors

Pre clinical and clinical studies of the effects of resveratrol, a phytochemical with potential chemopreventive efficacy

Resveratrol, found in grape skins and red wine, has potential chemopreventive activity in vitro at concentrations ≥5μM. This project explored the tolerability, pharmacokinetics and pharmacodynamics of resveratrol in two clinical phase 1 studies. In vivo data were supported by in vitro studies designed to mimic the daily dosing protocol, using concentrations observed clinically. Forty healthy volunteers received 29 oral daily doses of 0.5, 1.0, 2.5 and 5.0g resveratrol and 20 colorectal cancer patients 8 oral daily doses of 0.5 and 1.0g prior to surgical resection. The pharmacodynamics of resveratrol were assessed by measuring changes in plasma levels of proteins involved in the IGF system, oxidative DNA damage in whole blood and colorectal tissue (M1dG), effects on inflammatory pathways in plasma (PGE2) and colorectal tissue (COX-2), as well as colorectal tissue proliferation (Ki-67). No serious adverse events were reported. In volunteers, mean peak plasma levels of resveratrol across the dose groups ranged from 44.7-954ng/mL (0.20-4.20μM), and for the main metabolite, resveratrol-3-sulfate, were 4-13 fold-higher. Despite low systemic bioavailability, resveratrol concentrations associated with potential chemopreventive efficacy were observed in colorectal tumour tissue with a mean of 44.0nmol/g detected in patients receiving the 1.0g dose (range 0.30-195nmol/g). Post dosing, IGF-1 levels were reduced by 8% (P=0.03) in volunteers and by 33% (P<0.001) in colorectal cancer patients. In tissue, a reduction in cell proliferation of 5.5% (P=0.05) was observed, whilst there was an increase in COX-2 staining (P=0.004). Apart from the 2.5g dose in volunteers, where a significant increase was observed in blood M1dG (21.6%, P=0.02), resveratrol did not significantly affect plasma PGE2 or markers of DNA damage in either study. In cultured colon cancer cells, daily exposure to resveratrol was associated with increased antiproliferative activity compared to an equivalent single dose, supporting the indication that chronic administration may cause pharmacodynamic changes in humans. The work presented here suggests resveratrol has potential as a cancer chemopreventive agent and controlled clinical trials are now warranted.EThOS - Electronic Theses Online ServiceGBUnited Kingdo